Methandienone is used to treat the following disorders: protein synthesis disorders, cachexia of diverse genesis; trauma, burns, pre- and postoperative infectious diseases and after irradiation; renal and adrenal, toxic goiter, muscular dystrophy, osteoporosis, negative nitrogen balance corticosteroid therapy, anemia and aplastic hypo. Also, it is used in the treatment of tuberculosis, osteomyelitis, asthma, hepatitis.
Metandienonum is not indicated to be used is there is hypersensitivity to the drug, prostate cancer, breast carcinoma in women with hypercalcemia, CPI, severe atherosclerosis,breast cancer in men, hepatic and renal function, acute and chronic prostatitis, pregnancy and lactation.
Methandienone is produced in 10 mg pills, orally administered. Due to its short action time 3.2 to 4.5 hours, it is necessary to administrate it at least twice a day in order to maintain the necessary concentration of methandienone in the blood. In order to avoid possible gastrointestinal pain, it is recommended to take the tablets during meals.
Methandienone is an anabolic medicine. When entering the cell nucleus, it stimulates the genetic apparatus of the cell, causing the synthesis of DNA, RNA, and structural proteins, activates the enzymes of tissue respiration chain and enhancing tissue respiration, oxidative phosphorylation, ATP synthesis and intracellular aggregation macroergic. The process leads to an increased anabolic activity and inhibits catabolic processes those caused by glucocorticoids. During the treatment period this medicine cases boosted muscle mass, reduce fat deposits, improves trophic tissues, promotes calcium deposits in the bones, retain nitrogen, phosphorus, sulfur, potassium, sodium and water in the body. It enhances hematopoietic erythropoietin synthesis.
Methandienone administration in women can cause virilization symptoms. Although methandienone 10mg has many potential side effects, they are rare with a dosage of up to 20 mg per day. Methandienone 10mg has a strong effect on the liver that why a long-term therapy is liver-toxic. Even a dosage of only 10 mg./day has a noticeable strain on the liver but after the administration is stopped, the liver values return to normal. During Methandienone treatment, high blood pressure can happen along with fastened heartbeats which may require the administration of antihypertensive drugs. Metandienone therapy requires additional medicines like Tamoxifen and Provimed, as this anabolic medicine is likely to convert into estrogen.
Matandienon can cause a serious acne on the face, neck, chest, back, and shoulders since the sebaceous gland function are stimulated. In case a hereditary predisposition exists, metandienone can cause a possible balding.
After the treatment with metandienone, the patients feel a noticeable loss in weight and strength, due to the water excretion from the body, as it was retained in the body during the treatment period. If high dosages are administered aggressive behavior occasionally be observed.
In case an overdose with Methandienone is suspected, seek emergency help.